Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.
Dev Cell
; 11(1): 105-15, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16824957
ABSTRACT
Asymmetric cell division is a mechanism for achieving cellular diversity. In C. elegans, many asymmetric cell divisions are controlled by the Wnt-MAPK pathway through POP-1/TCF. It is poorly understood, however, how POP-1 determines the specific fates of daughter cells. We found that nob-1/Hox, ceh-20/Pbx, and a Meis-related gene, psa-3, are required for asymmetric division of the T hypodermal cell. psa-3 expression was asymmetric between the T cell daughters, and it was regulated by POP-1 through a POP-1 binding site in the psa-3 gene. psa-3 expression was also regulated by NOB-1 and CEH-20 through a NOB-1 binding sequence in a psa-3 intron. PSA-3 can bind CEH-20 and function after the T cell division to promote the proper fate of the daughter cell. These results indicate that cooperation between Wnt signaling and a Hox protein functions to determine the specific fate of a daughter cell.
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Base de dados:
MEDLINE
Assunto principal:
Caenorhabditis elegans
/
Proteínas de Homeodomínio
/
Proteínas de Caenorhabditis elegans
/
Proteínas Wnt
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article