[Clinical research on effects of shenfu injection in different dosage in preventing heart failure occurred in patients of acute myocardial infarction with elevated ST segment].

OBJECTIVE: To study the preventive effect of Shenfu Injection (SI) in different dosage on occurrence of heart failure in patients of acute myocardial infarction (MI) with elevated ST segment. METHODS: Ninety-seven patients of MI were divided into 3 groups, all were treated with conventional therapy, but to the SI treated groups, intravenous injection of low (0.3 ml/kg) or high dose (0.6 ml/kg) of SI were given once a day additionally. After 14 days' treatment, the incidence of heart failure and its severity were observed and evaluated with Killip grading. RESULTS: There was no significant difference in the incidence of heart failure among the 3 groups, but the severity of heart failure in the SI treated groups was remarkably milder than that in the control group, and the high dose SI showed the effect superior to that of low dose SI. CONCLUSION: Based on the conventional treatment, Shenfu Injection is helpful for alleviating the severity of heart failure.