Prior cocaine exposure disrupts extinction of fear conditioning.
Learn Mem
; 13(4): 416-21, 2006.
Article
em En
| MEDLINE
| ID: mdl-16847305
ABSTRACT
Psychostimulant exposure has been shown to cause molecular and cellular changes in prefrontal cortex. It has been hypothesized that these drug-induced changes might affect the operation of prefrontal-limbic circuits, disrupting their normal role in controlling behavior and thereby leading to compulsive drug-seeking. To test this hypothesis, we tested cocaine-treated rats in a fear conditioning, inflation, and extinction task, known to depend on medial prefrontal cortex and amygdala. Cocaine-treated rats conditioned and inflated similar to saline controls but displayed slower extinction learning. These results support the hypothesis that control processes in the medial prefrontal cortex are impaired by cocaine exposure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Córtex Pré-Frontal
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Cocaína
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Extinção Psicológica
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Medo
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article