T cells and their partners: The chemokine dating agency.
Trends Immunol
; 27(9): 421-7, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16860609
ABSTRACT
Chemokines and their receptors have long been recognized as key molecules directing leukocyte migration between blood, lymph and tissues. Evidence accumulated in recent years indicates that, in addition to their chemotactic functions, chemokine receptors are highly versatile players fine-tuning immune responses. Chemokine receptors and ligands have been implicated in dendritic-cell maturation, signal transmission at the immunological synapse between T lymphocytes and their cellular partners, and in the polarization of immune responses. These findings identify new roles for chemokines in T-cell triggering and activation of effector functions, and suggest that these small cytokines represent key conductors of adaptive immunity.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Quimiocinas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article