Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis.
J Neuroimmunol
; 178(1-2): 130-9, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16870268
ABSTRACT
This study characterized immunomodulatory targets of statins in humans and their potential for treatment of relapsing remitting multiple sclerosis (RR MS). Statins inhibited the proliferative response of mononuclear cells. Simvastatin, the statin with the strongest antiproliferative effect, inhibited IFN-gamma-induced expression of MHC class II DR on monocytes and decreased their antigen presenting capacity. As for T lymphocytes, it inhibited their activation and expression of the Th1 lineage differentiation markers. Simvastatin inhibited IFN-gamma, TNF-alpha, and IL-2 secretion, as well as the expression of T-bet, a transcription factor that regulates Th1 cell differentiation.
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Base de dados:
MEDLINE
Assunto principal:
Células Th1
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Esclerose Múltipla Recidivante-Remitente
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article