Fungal infection of implantable cardioverter-defibrillators: case series of five patients managed over 22 years.
Heart Rhythm
; 3(8): 919-23, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16876740
ABSTRACT
BACKGROUND:
With the increasing use of implantable cardioverter-defibrillators (ICDs), device complications are becoming more common. Fungal-related ICD infections have rarely been reported, and little is known about the presentation, prevalence, and treatment options for these morbid infections.OBJECTIVES:
The purpose of this study was to characterize the clinical features, treatment, and outcomes of patients with fungal ICD infections.METHODS:
We performed a retrospective review of ICD procedures performed at a single academic center and identified all ICD-related infections managed between 1983 and 2005.RESULTS:
Among a total of 3,648 ICD-related procedures performed between 1983 and 2005, we identified 47 (1.3%) cases of ICD infections, of which 5 (0.1%) were due to a fungal pathogen. Fungal infections were more likely to be associated with abdominal devices, to have a local rather than systemic infection, and to have a longer duration from the original implant to presentation. All patients were treated with ICD system explantation and antifungal therapy.CONCLUSION:
Fungal infection of ICDs is a rare but serious complication of device implantation that must be treated aggressively with complete hardware explantation and prolonged antifungal therapy. Because most infections are late complications and have indolent onsets, a high level of clinical suspicion is required for early diagnosis.
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Base de dados:
MEDLINE
Assunto principal:
Aspergilose
/
Aspergillus niger
/
Candidíase
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Infecções Relacionadas à Prótese
/
Desfibriladores Implantáveis
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article