[Correlation between hepatic immunological markers and virus genotype in patients with chronic hepatitis C].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 23(4): 452-5, 2006 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-16883540
ABSTRACT
OBJECTIVE:
To investigate the hepatic expression of immunological markers relevant to a cytotoxic response in relation to viral genotype.METHODS:
The frozen liver biopsies were obtained from 28 HF genotyped patients and made the sections stained. The morphometry was used to analyze the major histocompatibility complex class I (MHC-I), CD8, beta(2)-microglobulin (beta(2) -mG), HFE and CD68 in the stained sections. Biopsy data of response to therapy with interferon were available in 18 cases.RESULTS:
CD8+ was usually clustered together and localized in portal tracts and sinusoids, and seen to interact with MHC I positive lining cells. MHC-I and beta(2) -mG were expressed mainly in endothelial and Kupffer cells. HFE was expressed in most round and dendritic CD68+ cells. Patients with virus genotype 3a had higher hepatic MHC-I and HFE expression, and a better sustained response to interferon (IFN) therapy than patients without.CONCLUSION:
The MHC-I expression in the liver of patient with chronic hepatitis C virus infection seems to relate to viral-genotype. The hepatic MHC-I and HFE expression are higher in patients with virus genotype 3a than that in patients with non-3a genotype.
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Base de dados:
MEDLINE
Assunto principal:
Hepacivirus
/
Hepatite C Crônica
/
Fígado
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article