Antibacterial peptides for therapeutic use: obstacles and realistic outlook.
Curr Opin Pharmacol
; 6(5): 468-72, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16890021
ABSTRACT
Cationic antimicrobial peptides are produced by almost all species of life as a component of their immediate non-specific defense against infections. The assets of these peptides in clinical application include their potential for broad-spectrum activity, rapid bactericidal activity and low propensity for resistance development, whereas possible disadvantages include their high cost, limited stability (especially when composed of L-amino acids), and unknown toxicology and pharmacokinetics. Initial barriers to their success are being increasingly overcome with the development of stable, more cost-effective and potent broad-spectrum synthetic peptides. Thus, there is hope that they will spawn a new generation of antimicrobials with a broad range of topical and systemic applications against infections.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos Catiônicos Antimicrobianos
/
Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article