Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.
Nat Cell Biol
; 8(9): 1032-4, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16892052
ABSTRACT
DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5-Smc6 complex is recruited to DSBs de novo to support their repair by homologous recombination between sister chromatids. In addition, we demonstrate that Smc5-Smc6 is necessary to suppress gross chromosomal rearrangements. Our findings show that the Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events.
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Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Troca de Cromátide Irmã
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Dano ao DNA
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Proteínas de Ciclo Celular
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Proteínas de Saccharomyces cerevisiae
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article