Plasma lipid concentrations after 1.5 years of exposure to nevirapine or efavirenz together with stavudine and lamivudine.
HIV Med
; 7(6): 347-50, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16903977
ABSTRACT
OBJECTIVES:
To assess long-term changes in lipids and lipoproteins concentrations associated with exposure to non-nucleoside reverse transcriptase inhibitors.METHODS:
Long-term analysis of plasma lipid concentrations was performed in patients starting first-line antiretroviral therapy with stavudine (d4T) and lamivudine, and either nevirapine or efavirenz.RESULTS:
Concentrations of total cholesterol, low-density lipoprotein cholesterol and triglycerides continued to increase, while high-density lipoprotein cholesterol showed a slight decrease compared with earlier reported increases after 48 weeks.CONCLUSIONS:
Changes in body fat distribution expected to occur with continued exposure to d4T could offer a potential explanation for these findings.
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Base de dados:
MEDLINE
Assunto principal:
Oxazinas
/
Infecções por HIV
/
Estavudina
/
Inibidores da Transcriptase Reversa
/
Lamivudina
/
Fármacos Anti-HIV
/
Nevirapina
/
Lipídeos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article