Expression of the immediate early gene, c-fos, in fetal brain after whole of gestation exposure of pregnant mice to global system for mobile communication microwaves.
Pathology
; 38(4): 333-5, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16916723
ABSTRACT
AIMS:
To study immediate early gene, c-fos, expression as a marker of neural stress after whole of gestation exposure of the fetal mouse brain to mobile telephone-type radiofrequency fields.METHODS:
Using a purpose-designed exposure system at 900 MHz, pregnant mice were given a single, far-field, whole body exposure at a specific absorption rate of 4 W/kg for 60 min/day from day 1 to day 19 of gestation. Pregnant control mice were sham-exposed or freely mobile in a cage without further restraint. Immediately prior to parturition on gestational day 19, fetal heads were collected, fixed in 4% paraformaldehyde and paraffin embedded. Any stress response in the brain was detected by c-fos immunohistochemistry in the cerebral cortex, basal ganglia, thalamus, hippocampus, midbrain, cerebellum and medulla.RESULTS:
c-fos expression was of limited, but consistent, neuroanatomical distribution and there was no difference in immunoreactivity between exposed and control brains.CONCLUSION:
In this animal model, no stress response was detected in the fetal brain using c-fos immunohistochemistry after whole of gestation exposure to mobile telephony.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Genes fos
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Regulação da Expressão Gênica no Desenvolvimento
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Telefone Celular
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Micro-Ondas
Limite:
Animals
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Pregnancy
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article