Psychophysiological evidence for impaired reward anticipation in Parkinson's disease.
Clin Neurophysiol
; 117(10): 2144-53, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16920018
ABSTRACT
OBJECTIVE:
According to a widely held view, mesencephalic dopamine neurons mediate feedback-based learning by broadcasting an error signal that indexes the difference between anticipated and actual response-contingent reward. The present experiment tested whether impaired learning of a probabilistic classification task by individuals with Parkinson's disease (PD) is associated with abnormal reward expectation.METHODS:
The stimulus-preceding negativity (SPN), a brain potential known to reflect anticipation of motivationally significant events, was compared for blocks in which subjects anticipated high or low monetary rewards and punishments.RESULTS:
The SPN was reduced in amplitude in patients relative to controls in the high monetary incentive condition. Furthermore, whereas the SPN varied in size as a function of cue complexity for control subjects, it did not for patients.CONCLUSIONS:
These results suggest that anticipatory processes within cortical portions of the reward system are impaired by PD.SIGNIFICANCE:
These data support previous claims that the SPN offers an electrophysiological index of activity within cortical portions of the reward pathway, and that reinforcement-based learning is impaired in PD.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Recompensa
/
Encéfalo
/
Potenciais Evocados
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article