Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.
Virus Res
; 122(1-2): 144-53, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-16920215
ABSTRACT
Alternate serotypes of adenovirus (Ad), including Ads of species B, are being explored to circumvent the disadvantages of Ad serotype 5 gene delivery vectors. Whereas the majority of human Ads utilize the Coxsackievirus and adenovirus receptor (CAR), none of the Ad species B use CAR. Ad species B is further divided into two subspecies, B1 and B2, and utilizes at least two classes of receptors common Ad species B receptors and B2 specific receptors. CD46 has been implicated as a B2-specific receptor. Ad serotype 3 (Ad3), a member of B1, utilizes CD80 and CD86 as cellular attachment receptors. The receptor-interacting Ad fiber-knob domain is highly homologous among species B Ads. We hypothesized that other members of Ad species B may utilize CD80 and CD86 as cellular attachment receptors. All tested species B members showed specific binding to cells expressing CD80 and CD86, and the Ad fiber-knob domain from both B1 and B2 Ad efficiently blocked CD80- and CD86-mediated infection of Ad3 vectors. Members of both B1 and B2 demonstrated CD80- and CD86-specific infection of CHO cells expressing CD80 and CD86. Therefore, all of the members of Ad species B utilize CD80 and CD86 for infection of cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Virais
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Adenoviridae
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Antígeno B7-1
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Antígeno B7-2
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Ligação Viral
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article