Molecular epidemiology of hepatitis C virus subtype 3a in injecting drug users.
J Med Virol
; 78(10): 1296-303, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16927280
ABSTRACT
Hepatitis C virus subtype 3a (HCV-3a) originates from Asia and has spread widely among injecting drug users as well as other patient groups in industrialized countries. HCV subtype 3a infection remains highly prevalent and frequently transmitted in the population of intravenous drug users. The objective of this study was to understand better the mechanisms of the worldwide HCV-3a epidemics in drug users. Ninety-three sera from HCV-3a-infected IDUs from France, the United States, Brazil, Argentina, and Australia were studied. Phylogenetic analyses of the non-structural 5B region showed no specific clustering according to the continent of the patient's origin. Non-exclusive clusters of viral sequences from South America, Australia, and California were observed, but topologies were not supported by strong bootstrap values. The results suggest that HCV-3a has been transmitted from a common origin through a unique worldwide epidemic that rapidly spread among drug users. Regional transmission occurred in the recent past, leading to an embryonic genetic diversification of HCV-3a among local injecting drug user population.
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Base de dados:
MEDLINE
Assunto principal:
Abuso de Substâncias por Via Intravenosa
/
Hepatite C
/
Epidemiologia Molecular
/
Hepacivirus
Tipo de estudo:
Screening_studies
Limite:
Humans
País como assunto:
America do norte
/
America do sul
/
Argentina
/
Brasil
/
Europa
/
Oceania
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article