[Expression of E-cadherin and beta-catenin in Bowen's disease and squamous cell carcinoma].
Nan Fang Yi Ke Da Xue Xue Bao
; 26(8): 1245-7, 2006 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-16939929
ABSTRACT
OBJECTIVE:
To investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC).METHODS:
Fifteen normal skin, 28 BD and 18 SCC specimens were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed with semi-quantification of the pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining.RESULT:
Normal skins strongly expressed membranous E-cadherin and beta-catenin, but their expression was remarkably reduced in BD and SCC. Abnormal staining of beta-catenin was observed in the cytoplasm or cell nuclei of BD and SCC.CONCLUSION:
Abnormal expression of the E-cadherin/catenin complex is common in SCC and BD.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Doença de Bowen
/
Carcinoma de Células Escamosas
/
Caderinas
/
Beta Catenina
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article