The world of subinhibitory antibiotic concentrations.
Curr Opin Microbiol
; 9(5): 445-53, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16942902
ABSTRACT
Although antibiotics have long been known to have multiple effects on bacterial cells at low concentrations, it is only with the advent of genome transcription analyses that these activities have been studied in detail at the level of cell metabolism. It has been shown that all antibiotics, regardless of their receptors and mode of action, exhibit the phenomenon of hormesis and provoke considerable transcription activation at low concentrations. These analyses should be of value in providing information on antibiotic side-effects, in bioactive natural product discovery and antibiotic mode-of-action studies.
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Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Regulação Bacteriana da Expressão Gênica
/
Antibacterianos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article