Selection of a neutralization-escape variant strain of Japanese encephalitis virus using monoclonal antibody.
Indian J Med Res
; 91: 231-3, 1990 May.
Article
em En
| MEDLINE
| ID: mdl-1697849
ABSTRACT
An Indian strain of Japanese encephalitis virus (JEV), 733913, a human isolate from Bankura, West Bengal in 1973, with all the functional epitopes designated by a panel of murine monoclonal antibodies (MAbs), was treated with one of the JEV specific HI reactive MAb(Hs-I). This led to selection of a neutralization-escape variant which showed loss of reaction to three different MAbs belonging to the same domain (Hs) and assumed similar characteristics to another JEV strain (755468) also isolated from Bankura in 1975 from mosquitoes. It is possible that selection of such variant might occur in presence of pre-existing JE antibody (Hs-I type) in pigs which are amplifying hosts of JEV. Subsequent dissemination of such variant virus could occur through mosquitoes.
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Base de dados:
MEDLINE
Assunto principal:
Vírus da Encefalite Japonesa (Espécie)
/
Anticorpos Monoclonais
/
Antígenos Virais
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article