Inhibition of IL-2 induced IL-10 production as a principle of phase-specific immunotherapy.
J Immunol
; 177(7): 4636-43, 2006 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-16982902
ABSTRACT
Leishmania donovani, a protozoan parasite, inflicts a fatal disease, visceral leishmaniasis. The suppression of antileishmanial T cell responses that characterizes the disease was proposed to be due to deficiency of a T cell growth factor, IL-2. We demonstrate that during the first week after L. donovani infection, IL-2 induces IL-10 that suppresses the host-protective functions of T cells 14 days after infection. The observed suppression is concurrent with increased CD4+ glucocorticoid-induced TNF receptor+ T cells and Foxp3 expression in BALB/c mice, implicating IL-2-dependent regulatory T cell control of antileishmanial immune responses. Indeed, IL-2 and IL-10 neutralization at different time points after the infection demonstrates their distinct roles at the priming and effector phases, respectively, and establishes kinetic modulation of ongoing immune responses as a principle of a rational, phase-specific immunotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Interleucina-2
/
Interleucina-10
/
Imunoterapia
/
Leishmaniose Visceral
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article