From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease.
J Alzheimers Dis
; 10(1): 81-7, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16988485
ABSTRACT
Glutamate toxicity through NMDA receptor channels has long been central to the understanding of acute neuronal injury. Recent studies implicate similar events in chronic neurodegenerative diseases. Here, we analyze some of the most intriguing evidence for NMDA receptor-mediated cellular dysfunction and propose a mechanism by which hyperactive NMDA receptors might lead to neurofibrillary degeneration in Alzheimer's disease.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas tau
/
Receptores de N-Metil-D-Aspartato
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article