Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.
Bioorg Med Chem Lett
; 16(24): 6328-33, 2006 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-17005394
ABSTRACT
PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models of type 2 diabetes.
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Base de dados:
MEDLINE
Assunto principal:
Cinamatos
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Receptores Ativados por Proliferador de Peroxissomo
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article