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Characterization of HLA-B*5516, -B*1313, -B*9512, and -DRB1*1457 alleles identified in a southwest Chinese population.
Chen, Q; Zou, H; Xu, X H; Luo, M; Wang, J; Zuo, Y Q; Chen, Y H; Chen, X H; Chen, X L; Yao, Z Q; Song, N; Zeng, J; Mi, X Y; Sun, S X; Wang, J X; Zhao, T M.
Afiliação
  • Chen Q; Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China. xiet@mail.sc.cninfo.net
Tissue Antigens ; 68(4): 339-43, 2006 Oct.
Article em En | MEDLINE | ID: mdl-17026471
The human leukocyte antigen (HLA)-B*5516 allele differs from the B*5502 by a single 97 T --> C substitution (His to Tyr at position 33) in exon 2. The B*1313 allele results from 419 T --> A and 420 A --> C substitutions, encoding a Leu to Tyr substitution at 140 in exon 2 of the B*1301 allele. The B*9512 allele differs from B*1502 by a single 360 G --> C substitution (Gln to His at 120) in exon 3. The DRB1*1457 allele appears to be a hybrid molecule generated by recombination between the DRB1*13 and DRB1*14 alleles. The serological equivalents of these new alleles are HLA-B22, -B13, -B15, and DR13, respectively. Family studies detected two rare haplotypes: A*11, B*9512, DRB1*14 and A*24, B*52, Cw*07, DRB1*1457, DRB3*020201, DQB1*050301. The gene frequencies of these alleles in the Chinese population are less than 0.0001.
Assuntos
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Base de dados: MEDLINE Assunto principal: Antígenos HLA-B / Antígenos HLA-DR / Alelos Limite: Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Antígenos HLA-B / Antígenos HLA-DR / Alelos Limite: Humans Idioma: En Ano de publicação: 2006 Tipo de documento: Article