Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells.
FEBS Lett
; 580(25): 5905-9, 2006 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-17027756
ABSTRACT
BH3-only proteins are required for execution of apoptotic cell death. We have found that one of these proteins, Bik, is strongly induced in cancer cells treated with chemotherapeutic agents. Furthermore, we showed that chemotherapy-induced expression of bik is independent of p53. Consistent with its pro-apoptotic activity, blockade of bik expression reduces the adriamycin-mediated apoptotic cell death. We also found that the bik gene is transcriptionally activated by E2F proteins. Consistently, adriamycin induces the E2F-bik pathway. In addition, E2Fs transactivate bik by a p53-independent mechanism. Thus, our data indicate that transcriptional regulation of bik contributes to the efficient apoptotic response to chemotherapeutic agents.
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Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Proteínas Reguladoras de Apoptose
/
Fatores de Transcrição E2F
/
Proteínas de Membrana
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article