Expression of nestin and vimentin in gliomatosis cerebri.
Arq Neuropsiquiatr
; 64(3B): 781-6, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-17057885
ABSTRACT
Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tumor cells were negative for GFAP, even though there were foci of positivity for this marker in all cases. We detected the presence of many positive cells for nestin and vimentin in all studied samples. The presence of these cells may indicate origin of the tumor from undifferentiated cells with a high degree of mobility.
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Base de dados:
MEDLINE
Assunto principal:
Astrocitoma
/
Vimentina
/
Neoplasias Encefálicas
/
Biomarcadores Tumorais
/
Proteínas de Filamentos Intermediários
/
Proteínas do Tecido Nervoso
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article