Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.
J Cell Biol
; 175(2): 209-15, 2006 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-17060494
ABSTRACT
Toll receptors in Drosophila melanogaster function in morphogenesis and host defense. Mammalian orthologues of Toll, the Toll-like receptors (TLRs), have been studied extensively for their essential functions in controlling innate and adaptive immune responses. We report that TLR8 is dynamically expressed during mouse brain development and localizes to neurons and axons. Agonist stimulation of TLR8 in cultured cortical neurons causes inhibition of neurite outgrowth and induces apoptosis in a dissociable manner. Our evidence indicates that such TLR8-mediated neuronal responses do not involve the canonical TLR-NF-kappaB signaling pathway. These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity.
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Base de dados:
MEDLINE
Assunto principal:
Neuritos
/
Apoptose
/
Receptor 8 Toll-Like
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article