From the genome to the proteome: uncovering peptides in the Apis brain.
Science
; 314(5799): 647-9, 2006 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-17068263
ABSTRACT
Neuropeptides, critical brain peptides that modulate animal behavior by affecting the activity of almost every neuronal circuit, are inherently difficult to predict directly from a nascent genome sequence because of extensive posttranslational processing. The combination of bioinformatics and proteomics allows unprecedented neuropeptide discovery from an unannotated genome. Within the Apis mellifera genome, we have inferred more than 200 neuropeptides and have confirmed the sequences of 100 peptides. This study lays the groundwork for future molecular studies of Apis neuropeptides with the identification of 36 genes, 33 of which were previously unreported.
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Base de dados:
MEDLINE
Assunto principal:
Abelhas
/
Neuropeptídeos
/
Genes de Insetos
/
Proteínas de Insetos
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article