Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans.
Mech Ageing Dev
; 128(1): 92-105, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17116321
ABSTRACT
A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging. Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies, and should be addressed and studied within an evolutionary-based systems biology perspective. Evidence in favor of this conceptualization largely derives from studies in humans. We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Mediadores da Inflamação
/
Inflamação
/
Longevidade
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article