Long-lasting regeneration after ischemia in the cerebral cortex.
Stroke
; 38(1): 153-61, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17122419
ABSTRACT
BACKGROUND AND PURPOSE:
Because fibroblast growth factor 2 is a mitogen for central nervous system stem cells, we explored whether long-term fibroblast growth factor 2 delivery to the brain can improve functional outcome and induce cortical neurogenesis after ischemia.METHODS:
Rats underwent permanent distal middle cerebral artery occlusion resulting in an ischemic injury limited to the cortex. We used an adeno-associated virus transfection system to induce long-term fibroblast growth factor 2 expression and monitored behavioral and histological changes.RESULTS:
Treatment increased the number of proliferating cells and improved motor behavior. Neurogenesis continued throughout 90 days after the ischemia, and the occurrence of newly generated cells with characteristics of neural precursors and immature neurons was most evident 90 days after treatment.CONCLUSIONS:
Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome.
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Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Córtex Cerebral
/
Isquemia Encefálica
/
Fator 2 de Crescimento de Fibroblastos
/
Infarto Encefálico
/
Regeneração Nervosa
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article