A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii.
J Antibiot (Tokyo)
; 59(9): 597-600, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-17136892
ABSTRACT
In screening for antifungal substances, a new macrolide, eushearilide (1), was isolated from Eupenicillium shearii IFM54447. The structure of 1 was established to be 24-membered macrolide having a non-conjugated diene and a choline phosphate ester moetiy on the basis of detailed investigation of NMR, UV, IR and MS spectral data. Compound 1 showed antifungal activity against various fungi and yeasts, including human pathogens Aspergillus fumigatus, Trichophyton spp. and Candida spp.
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Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
/
Macrolídeos
/
Eurotiales
/
Antifúngicos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article