Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.
J Neuroimmunol
; 182(1-2): 226-31, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17156857
ABSTRACT
One form of juvenile onset autosomal recessive amyotrophic lateral sclerosis (ALS2) has been linked to the dysfunction of the ALS2 gene. The ALS2 gene is expressed in lymphoblasts, however, whether ALS2-deficiency affects periphery blood is unclear. Here we report that ALS2 knockout (ALS2(-/-)) mice developed peripheral lymphopenia but had higher proportions of hematopoietic stem and progenitor cells in which the stem cell factor-induced cell proliferation was up-regulated. Our findings reveal a novel function of the ALS2 gene in the lymphopoiesis and hematopoiesis, suggesting that the immune system is involved in the pathogenesis of ALS2.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Troca do Nucleotídeo Guanina
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Linfopoese
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Hematopoese
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Linfopenia
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article