Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
J Exp Med
; 203(13): 2793-9, 2006 Dec 25.
Article
em En
| MEDLINE
| ID: mdl-17158963
ABSTRACT
The ataxia telangiectasia mutated (ATM) kinase is a key tumor suppressor that regulates numerous cell cycle checkpoints as well as apoptosis. Here, we report that ATM is a critical player in the regulation of apoptosis and lymphomagenesis in the presence of c-myc. In turn, deletion of the inhibitory ATM phosphatase, Wip1, results in ATM up-regulation and suppression of Emicro-myc-induced B cell lymphomas. Using mouse genetic crosses, we show that the onset of myc-induced lymphomas is dramatically delayed in Wip1-null mice in an ATM- and p53-, but not p38 MAPK- or Arf-, dependent manner. We propose that Wip1 phosphatase is critical for regulating the ATM-mediated tumor surveillance network.
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Base de dados:
MEDLINE
Assunto principal:
Proteína Supressora de Tumor p53
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Proteínas Proto-Oncogênicas c-myc
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Proteínas Serina-Treonina Quinases
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Fosfoproteínas Fosfatases
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Proteínas de Ciclo Celular
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Proteínas Supressoras de Tumor
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Proteínas de Ligação a DNA
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Linfoma
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Proteínas de Neoplasias
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article