From genome to proteome in tumor profiling: molecular events in colorectal cancer genesis.
Adv Exp Med Biol
; 587: 161-77, 2006.
Article
em En
| MEDLINE
| ID: mdl-17163165
ABSTRACT
Biomedical research has advanced rapidly in recent years with the sequencing of the human genome and the availability of technologies such as global gene and protein expression profiling using different chip platforms. However, this progress has not yet been transferred to the bedside. While detection of cancer at early stages is critical for curative treatment interventions, efficient diagnostic and therapeutic markers for the majority of malignancies still seem to be lacking. Comprehensive tumor profiling has therefore become a field of intensive research aiming at identifying biomarkers relevant for improved diagnostics and therapeutics. This chapter will demonstrate a genomic and proteomic approach while focusing on tumor profiling during colorectal cancer development.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Perfilação da Expressão Gênica
/
Genômica
/
Proteômica
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article