[Late complications of chronic respiratory infections in patients with common variable immunodeficiency]. / Pozdní komplikace chronických zánetu respiracního traktu u nemocných s beznou variabilní imunodeficiencí.
Vnitr Lek
; 52(11): 1021-9, 2006 Nov.
Article
em Cs
| MEDLINE
| ID: mdl-17165520
ABSTRACT
Common variable immunodeficiency (CVID) is the most frequent serious humoral deficiency manifested in adulthood in the form of acute and chronic respiratory infections which in most patients lead to respiratory failure. Retrospective analysis of 28 CVID patients was made. Mean age at time of diagnosis was 38.6 +/- 18.6 years. The time which elapsed from the first symptoms to determining the diagnosis was three times as long as that indicated in other studies, i.e., 14.1 +/- 10.2 years. Twenty-three patients (82.1%) had respiratory complications. Chronic obstructive pulmonary diseases, n=16 (57.1%), and bronchiectasis, n=10 (35.7%), were the most frequent types of lung damage. In addition, two patients (7.1%) displayed evidence of interstitial lung process. Morbidity associated with CVID can be reduced by early diagnosis and adequate dosage of immunoglobulins to minimise the occurrence and progression of lung damage.
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Base de dados:
MEDLINE
Assunto principal:
Infecções Respiratórias
/
Imunodeficiência de Variável Comum
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Screening_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Cs
Ano de publicação:
2006
Tipo de documento:
Article