Cerebrospinal fluid levels of myelin basic protein-like material and soluble interleukin-2 receptor in multiple sclerosis.
J Neuroimmunol
; 34(1): 77-80, 1991 Oct.
Article
em En
| MEDLINE
| ID: mdl-1716642
ABSTRACT
The presence, level and disease activity relationships of soluble interleukin-2 receptor (sIL-2R) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients are unresolved. We measured CSF immunoreactive myelin basic protein (MBP), a marker of acute myelin damage, and sIL-2R levels in the CSF from 11 patients with active relapsing remitting (RR) MS, five with stable RR MS, eight with chronic progressive (CP) MS, five with other neurologic diseases, and three normal controls. No measurable (less than 100 units/ml) sIL-2R was present in any of the samples. Conversely, MBP levels were elevated in the active RR group compared to the other four groups. These results indicate that, at the sensitivity of assays currently available, levels of CSF sIL-2R do not correlate with the diagnosis or disease activity of MS.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Interleucina-2
/
Proteína Básica da Mielina
/
Esclerose Múltipla
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article