Visual activity and cortical rewiring: activity-dependent plasticity of cortical networks.
Prog Brain Res
; 157: 3-11, 2006.
Article
em En
| MEDLINE
| ID: mdl-17167899
ABSTRACT
The mammalian cortex is organized anatomically into discrete areas, which receive, process, and transmit neural signals along functional pathways. These pathways form a system of complex networks that wire up through development and refine their connections into adulthood. Understanding the processes of cortical-pathway formation, maintenance, and experience-dependent plasticity has been among the major goals of contemporary neurobiology. In this chapter, we will discuss an experimental model used to investigate the role of activity in the patterning of cortical networks during development. This model involves the "rewiring" of visual inputs into the auditory thalamus and subsequent remodeling of the auditory cortex to process visual information. We review the molecular, cellular, and physiological mechanisms of visual "rewiring" and activity-dependent shaping of cortical networks.
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Base de dados:
MEDLINE
Assunto principal:
Visão Ocular
/
Córtex Visual
/
Córtex Cerebral
/
Rede Nervosa
/
Plasticidade Neuronal
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article