Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.
J Exp Med
; 204(1): 7-10, 2007 Jan 22.
Article
em En
| MEDLINE
| ID: mdl-17190841
ABSTRACT
Somatic hypermutation (SHM) introduces nucleotide substitutions into immunoglobulin variable (Ig V) region genes at all four bases, but the mutations at C/G and A/T pairs are achieved by distinct mechanisms. Mutations at C/G pairs are a direct consequence of the C-->U deamination catalyzed by activation-induced deaminase (AID). Mutations at A/T pairs, however, require a second mutagenic process that occurs during patch repair of the AID-generated U/G mismatch. Several DNA polymerases have been proposed to play a role in SHM, but accumulating evidence indicates that the mutations at A/T are overwhelmingly achieved by recruitment of DNA polymerase eta.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citidina Desaminase
/
Hipermutação Somática de Imunoglobulina
/
DNA Polimerase Dirigida por DNA
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article