Radioresistant derivatives of radiosensitive CHO cells obtained following treatment with 5-azacytidine retain their sensitivity to cisplatin.
Radiat Res
; 127(2): 226-9, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1719578
ABSTRACT
Treatment of the radiation-sensitive CHO mutant, xrs-5, with the demethylating agent 5-azacytidine results in the complete conversion to wild-type levels of X-ray resistance in 50% of the colonies examined (10/20). In addition to being sensitive to X rays, xrs-5 is also sensitive to the killing effects of the crosslinking agent cisplatin. The 5-azacytidine-treated xrs-5 cells which exhibit wild-type survival levels following exposure to X rays failed to demonstrate conversion to wild-type levels of resistance to cisplatin. These results support the hypothesis that increases in gene expression can alter the radioresistance of xrs-5 cells without influencing the cells' survival after exposure to cisplatin.
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Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
/
Azacitidina
/
Cisplatino
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article