Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.
Drug Discov Today
; 12(1-2): 28-33, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17198970
ABSTRACT
RNA interference (RNAi) and small-molecule approaches are synergistic on multiple levels, from technology and high-throughput screen development to target identification and functional studies. Here, we describe the RNAi screening platform that we have established and made available to the community through the Drosophila RNAi Screening Center at Harvard Medical School. We then illustrate how the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery.
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Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Interferência de RNA
/
Avaliação Pré-Clínica de Medicamentos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article