Neurophysiology: Hodgkin and Huxley model--still standing?
Nature
; 445(7123): E1-2; discussion E2-3, 2007 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-17203021
ABSTRACT
Action potentials in cortical neurons show a variable threshold and a sudden rise in membrane potential at initiation. Naundorf et al. fail to explain these features using single- or double-compartment Hodgkin-Huxley-style models, suggesting instead that they could arise from cooperative opening of Na+ channels, although there is no direct biological evidence to support this. Here we show that these so-called unique features are to be expected from Hodgkin-Huxley models if the spatial geometry and spike initiation properties of cortical neurons are taken into account--it is therefore unnecessary to invoke exotic channel-gating properties as an explanation.
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Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Canais de Sódio
/
Células Piramidais
/
Modelos Neurológicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article