Local delivery of antimicrobial drugs in the treatment of chronic adult periodontitis.
Minerva Stomatol
; 55(11-12): 655-61, 2006.
Article
em En, It
| MEDLINE
| ID: mdl-17211371
ABSTRACT
AIM:
The aim of this study was to evaluate the clinical and microbiologic results of local delivery of adjunctive antimicrobials in the treatment and management of patients with periodontitis.METHODS:
The study population included 33 patients (age range, 37-49 years), with chronic adult periodontitis. Eleven of 33 received local treatment with 10% doxycycline injected directly into the periodontal pocket; 11 received local treatment with a chlorhexidine-based gel (1.5%) in situ; 11 received mechanical treatment with scaling and root planing. The crevicular fluid of the doxycycline-treated group was analyzed using high performance liquid chromatography over a period of 1 month.RESULTS:
In the 11 patients treated with an antibiotic we observed a reduction in attachment loss and a reduction in probing depth of 1.4 mm; in the 11 chlorhexidine-treated patients we observed a reduction in attachment loss and a reduction in probing depth of 0.9 mm; in the remaining 11 patients the reduction in attachment loss and probing depth was less than those measured in the other two treatment groups.CONCLUSIONS:
Our results suggest that direct delivery of antimicrobial agents to the infection site may be a useful adjunctive to conventional periodontal treatment.
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Base de dados:
MEDLINE
Assunto principal:
Periodontite
/
Clorexidina
/
Doxiciclina
/
Anti-Infecciosos Locais
/
Antibacterianos
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
/
It
Ano de publicação:
2006
Tipo de documento:
Article