The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists.
Bioorg Med Chem
; 15(5): 2092-105, 2007 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-17236777
ABSTRACT
The design, synthesis, and biological studies of a novel class of MCH-R1 antagonists based on an aminotetrahydronaphthalene ketopiperazine scaffold is described. Compounds within this class promoted significant body weight reduction in mouse diet induced obesity studies. The potential for hERG blockage activity and QT interval studies in anesthetized dogs are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Receptores de Somatostatina
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article