Measurement of acute myocardial infarcts in dogs with 99mTc-stannous pyrophosphate scintigrams.
J Nucl Med
; 17(1): 1-5, 1976 Jan.
Article
em En
| MEDLINE
| ID: mdl-172612
ABSTRACT
Myocardial scintigrams using 99mTc-stannous pyrophosphate (99mTc-PYP) can be used to measure myocardial infarcts produced in dogs by proximal ligation of the left anterior descending coronary artery. Seven dogs had 99mTc-PYP myocardial scintigraphy performed 24--32 hr after ligation of the proximal left anterior artery. In each dog the scintigrams showed increased 99mTc-PYP uptake in the distribution of the artery. The scintigraphically visible areas of infarction, measured using interactive computer-aided techniques, were compared subsequently with independent histologic measurements of myocardial infarct size. Several methods for using the area measurements to estimate infarct size were tested. The most successful method (r = 0.92, p less than 0.01) assumed a linear relationship between the largest scintigraphic infarct area and the histologically determined infarct weight. The results suggest that 99mTc-PYP myocardial scintigrams provide a useful noninvasive method for measuring infarct size in dogs with proximal ligation of the left anterior descending coronary artery.
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Base de dados:
MEDLINE
Assunto principal:
Cintilografia
/
Tecnécio
/
Difosfatos
/
Infarto do Miocárdio
Limite:
Animals
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article