Pure red-cell aplasia secondary to pregnancy, characterization of a syndrome.
Ann Hematol
; 86(4): 233-7, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17262194
ABSTRACT
The aim of this study was to characterize the syndrome of pure red-cell aplasia (PRCA) secondary to pregnancy. All published cases of PRCA induced by pregnancy were reviewed. Additionally, we reported a patient who developed PRCA on three occasions; two were triggered by pregnancy and one after medroxyprogesterone administration. Ten patients with 13 pregnancy-induced PRCA episodes were reported. The PRCA occurred at any gestational age. All patients received blood transfusions, and six of them were treated corticosteroids. The PRCA resolved in all subjects postpartum. Five women had subsequent pregnancies; three were complicated by PRCA, one was normal, and one had spontaneous abortion without PRCA. One subject developed a PRCA after long-term exposure to medroxyprogesterone. Infant blood values were normal in the nine reported cases. Pregnancy-induced PRCA is a self-limited syndrome with a high risk for relapse during subsequent pregnancies. It can be managed by blood transfusions. Progestins might cause PRCA in these women.
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Base de dados:
MEDLINE
Assunto principal:
Complicações Hematológicas na Gravidez
/
Aplasia Pura de Série Vermelha
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article