Molecular pathogenesis of osteosarcoma.
DNA Cell Biol
; 26(1): 1-18, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17263592
ABSTRACT
Osteosarcoma is a devastating but rare disease, whose study has illuminated both the basic biology and clinical management of cancer over the past 30 years. These contributions have included insight into the roles of key cancer genes such as the retinoblastoma tumor suppressor gene and TP53, the identification of familial cancer syndromes implicating DNA helicases, and dramatic improvements in survival by the use of adjuvant chemotherapy. This review provides a synoptic overview of our current understanding of the molecular causes of osteosarcoma, and suggests future directions for study.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ósseas
/
Osteossarcoma
Tipo de estudo:
Etiology_studies
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article