Efficacy and safety of hyaluronan treatment in combination therapy with home exercise for knee osteoarthritis pain.
Arch Phys Med Rehabil
; 88(2): 135-41, 2007 Feb.
Article
em En
| MEDLINE
| ID: mdl-17270509
ABSTRACT
OBJECTIVE:
To assess the efficacy and safety of intra-articular injections of sodium hyaluronate combined with a home exercise program (HEP) in the management of pain associated with osteoarthritis (OA) of the knee.DESIGN:
Single-blinded, parallel-design, 1-year clinical study with sequential enrollment.SETTING:
University-based outpatient physiatric practice.PARTICIPANTS:
Sixty patients (18 men, 42 women; age, > or =50 y) with moderate-to-severe pain associated with OA of the knee.INTERVENTIONS:
(1) Five weekly intra-articular hyaluronate injections (5-HYL); (2) 3 weekly intra-articular hyaluronate injections (3-HYL); or (3) a combination of an HEP with 3 weekly intra-articular hyaluronate injections (3-HYL+HEP). MAIN OUTCOMEMEASURES:
The primary outcome measure was a 100-mm visual analog scale for pain after a 50-foot walk (15.24 m). Secondary measures included the Western Ontario and McMaster Universities Osteoarthritis Index subscales.RESULTS:
The 3-HYL+HEP group had significantly faster onset of pain relief compared with the 3-HYL (P<.01) and 5-HYL groups (P=.01). All groups showed a mean symptomatic improvement from baseline (reduction in baseline pain at 3 mo was 59%, 49%, and 48% for the 3-HYL+HEP, 3-HYL, and 5-HYL groups, respectively) that was clinically and statistically significant. There were no between-group differences in the incidence or nature of adverse events.CONCLUSIONS:
The combined use of hyaluronate injections with HEP should be considered for management of moderate-to-severe pain in patients with knee OA.
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Base de dados:
MEDLINE
Assunto principal:
Adjuvantes Imunológicos
/
Osteoartrite do Joelho
/
Terapia por Exercício
/
Ácido Hialurônico
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article