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Effect of intravenous application of esomeprazole 40 mg versus pantoprazole 40 mg on 24-hour intragastric pH in healthy adults.
Hartmann, Dirk; Eickhoff, Axel; Damian, Ulrich; Riemann, Juergen F; Schilling, Dieter.
Afiliação
  • Hartmann D; Department of Medicine C (Gastroenterology), Academic Teaching Hospital of the Johannes-Gutenberg-University of Mainz, Ludwigshafen, Germany. medcluhartmann@t-online.de
Eur J Gastroenterol Hepatol ; 19(2): 133-7, 2007 Feb.
Article em En | MEDLINE | ID: mdl-17272998
BACKGROUND: It has been demonstrated that therapy with proton pump inhibitors reduces recurrence of bleeding following initial endoscopic treatment of bleeding peptic ulcers. AIM: This study compared the effects of esomeprazole 40 mg and pantoprazole 40 mg on intragastric acid control. Both substances were administered intravenously as 15-min infusion and as bolus injection. METHODS: Healthy men and women volunteers were enrolled in this single-center, open, randomized, three-way crossover study. After administration of esomeprazole 40 mg and pantoprazole 40 mg intravenously as 15-min infusion, and pantoprazole 40 mg intravenously as bolus injection, continuous 24-h intragastric pH monitoring was carried out. RESULTS: pH data were available for 21 Helicobacter pylori-negative and seven H. pylori-positive volunteers. In H. pylori-negative volunteers, esomeprazole 40 mg intravenously resulted in 11.8 h with an intragastric pH>4 compared with 5.6 h for pantoprazole 40 mg intravenously as infusion (P<0.0001), and 7.2 h for pantoprazole 40 mg intravenously as bolus injection (P<0.001). During the first 6 h of administration, the corresponding values were 3.4, 1.1 (P<0.000001), and 2.1 h (P<0.001), respectively. CONCLUSIONS: In H. pylori-negative patients, a single dose of esomeprazole 40 mg intravenously provides an intragastric acid control that is faster and more pronounced than administration of pantoprazole 40 mg intravenously.
Assuntos
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Base de dados: MEDLINE Assunto principal: 2-Piridinilmetilsulfinilbenzimidazóis / Esomeprazol / Ácido Gástrico / Antiulcerosos Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: 2-Piridinilmetilsulfinilbenzimidazóis / Esomeprazol / Ácido Gástrico / Antiulcerosos Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2007 Tipo de documento: Article