Long-term upregulation of protein kinase A and adenylate cyclase levels in human smokers.
J Neurosci
; 27(8): 1964-72, 2007 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-17314292
ABSTRACT
Repeated injections of cocaine and morphine in laboratory rats cause a variety of molecular neuroadaptations in the cAMP signaling pathway in nucleus accumbens and ventral tegmental area. Here we report similar neuroadaptations in postmortem tissue from the brains of human smokers and former smokers. Activity levels of two major components of cAMP signaling, cAMP-dependent protein kinase A (PKA) and adenylate cyclase, were abnormally elevated in nucleus accumbens of smokers and in ventral midbrain dopaminergic region of both smokers and former smokers. Protein levels of the catalytic subunit of PKA were correspondingly higher in the ventral midbrain dopaminergic region of both smokers and former smokers. Protein levels of other candidate neuroadaptations, including glutamate receptor subunits, tyrosine hydroxylase, and other protein kinases, were within normal range. These findings extend our understanding of addiction-related neuroadaptations of cAMP signaling to tobacco smoking in human subjects and suggest that smoking-induced brain neuroadaptations can persist for significant periods in former smokers.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tegmento Mesencefálico
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Fumar
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Regulação para Cima
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Adenilil Ciclases
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Proteínas Quinases Dependentes de AMP Cíclico
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Núcleo Accumbens
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article