NT-proBNP levels and diastolic dysfunction in beta-thalassaemia major patients.
Eur J Heart Fail
; 9(5): 531-6, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17317307
ABSTRACT
BACKGROUND:
The early diagnosis and treatment of heart failure in beta-thalassaemic patients is related to survival. Iron alone or in combination with other factors causes diastolic dysfunction, which usually precedes systolic dysfunction. NT-proBNP is a sensitive biomarker of ventricular dysfunction.AIM:
To evaluate NT-proBNP in non heart failure beta-thalassaemic patients.METHODS:
Fifty-two beta-thalassaemia major patients (mean age 27.2+/-12.5 years) with normal LV systolic function, underwent NT-proBNP measurement and a thorough Doppler-echocardiographic and pulsed tissue-Doppler study, 4 days following blood transfusion. Fifty-two age matched healthy controls were also studied.RESULTS:
NT-proBNP and E/E' ratio were increased in thalassaemic patients compared with controls [(469+/-171 vs 262+/-51 pmol/l, p<0.001) and (10.8+/-4.0 vs 6.6+/-1.1, p<0.001)] and were well correlated (r 0.54, p<0.01). Although NT-proBNP levels were increased in patients with higher E/E' ratios (E/E' <8 354+/-119, 8-15 516+/-177, >15 565+/-114 pmol/l, ANOVA p 0.002) this increase only became statistically significant in the 3rd decade of life, while E/E' ratio increased in the 4th decade.CONCLUSION:
NT-proBNP increases in beta-thalassaemia major patients and is related to age and LV diastolic dysfunction. NT-proBNP appears to be an early biomarker of LV diastolic dysfunction, compared with the conventional Echo-Doppler indexes.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Talassemia beta
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Disfunção Ventricular Esquerda
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Peptídeo Natriurético Encefálico
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
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Screening_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article