Boundary lubrication of articular cartilage: role of synovial fluid constituents.
Arthritis Rheum
; 56(3): 882-91, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17328061
ABSTRACT
OBJECTIVE:
To determine whether the synovial fluid (SF) constituents hyaluronan (HA), proteoglycan 4 (PRG4), and surface-active phospholipids (SAPL) contribute to boundary lubrication, either independently or additively, at an articular cartilage-cartilage interface.METHODS:
Cartilage boundary lubrication tests were performed with fresh bovine osteochondral samples. Tests were performed using graded concentrations of SF, HA, and PRG4 alone, a physiologic concentration of SAPL, and various combinations of HA, PRG4, and SAPL at physiologic concentrations. Static (mu(static, Neq)) and kinetic (RESULTS:
Normal SF functioned as an effective boundary lubricant both at a concentration of 100% (CONCLUSION:
The results described here indicate that SF constituents contribute, individually and in combination, both at physiologic and pathophysiologic concentrations, to the boundary lubrication of apposing articular cartilage surfaces. These results provide insight into the nature of the boundary lubrication of articular cartilage by SF and its constituents. They therefore provide insight regarding both the homeostatic maintenance of healthy joints and pathogenic processes in arthritic disease.
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Base de dados:
MEDLINE
Assunto principal:
Líquido Sinovial
/
Cartilagem Articular
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article