Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients.
Anticancer Res
; 27(1B): 627-33, 2007.
Article
em En
| MEDLINE
| ID: mdl-17348452
ABSTRACT
BACKGROUND:
The relationship between chromosome 18q allelic imbalance (AI) and survival in colorectal cancer (CRC) is unclear, and study design may have contributed to inconsistent results previously reported. PATIENTS ANDMETHODS:
Two hundred and eighty tumours from CRC patients participating in a molecular sub-study from a single multicentre trial of adjuvant intra-portal 5-fluorouracil were genotyped at 5 chromosome 18q microsatellite markers, blinded to clinical data and prospective to follow-up. The relationship between overall survival and AI was examined.RESULTS:
Two hundred and fifty-five tumours were informative for AI. The overall rate of AI was 49%. AI was not associated with age, tumour site or size. There was no difference in five-year survival rate between patients with (60.0% SE 5.2%) and without AI (61.4% SE 5.0%), even after correcting for covariates (HR=1.17, 95%CI0.79-1.74, p=0.4).CONCLUSION:
Our data does not [corrected] support chromosome 18q AI as an important marker of survival in the adjuvant setting. It should not, therefore, be used outside clinical trials.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 18
/
Neoplasias Colorretais
/
Desequilíbrio Alélico
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article