Direct imaging of lipid-ion network formation under physiological conditions by frequency modulation atomic force microscopy.
Phys Rev Lett
; 98(10): 106101, 2007 Mar 09.
Article
em En
| MEDLINE
| ID: mdl-17358548
ABSTRACT
Various metal cations in physiological solutions interact with lipid headgroups in biological membranes, having an impact on their structure and stability, yet little is known about the molecular-scale dynamics of the lipid-ion interactions. Here we directly investigate the extensive lipid-ion interaction networks and their transient formation between headgroups in a dipalmitoylphosphatidylcholine bilayer under physiological conditions. The spatial distribution of ion occupancy is imaged in real space by frequency modulation atomic force microscopy with sub-Angstrom resolution.
Buscar no Google
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article